Mycobacterium Tuberculosis Correlative IFN-γ Release Assay (TB-IGRA)


TB-IGRA is an enzyme-linked immunosorbent assay for quantitative detection (2~400pg/ml) of Interferon Gamma (IFN-y) that respond to in-vitro stimulation by Mycobacterium tuberculosis antigens in human whole blood. It is intended for use as an aid in the diagnosis of tuberculosis (TB) infection, including both latent tuberculosis infection (LTBI) and tuberculosis (TB) disease.

IGRA measures a person's immune reactivity to M.tuberculosis. When infected with Mycobacterium tuberculosis, specific T-lymphocytes will appear in the blood of the patient, which will be stimulated to proliferate and release cytokines such as IFN-γ, when they are mixed with antigens derived from M.Tuberculosis. The concentration of IFN-γ is positively related with the quantity of tuberculosis antigens. TB-IGRA kit uses ELISA method for quantitative detection the specific IFN-γ released by cells to determine Mycobacterium tuberculosis infection.

The antigens selected for stimulation is specific fragments that pathogenic Mycobacterium tuberculosis have, but BCG vaccine and other Mycobacterium do not have. This increased the specificity of the TB-IGRA Assay kit. And this TB Assay kit is easier to operate than PCR, bacterial culture and SPOT. The TB-IGRA kit need no extra equipment than the usual plate Washer, plate reader, incubator. This TB assay kit can be used in the following realms:

  1. Active tuberculosis detection;
  2. Latent tuberculosis detection;
  3. TB therapeutic effect monitor;
  4. Medication instruction;
  5. Prevent TB cross infection.
TB-IGRA kit Testing Principle

TB Antibody Rapid Test Kits

TB Rapid Test Cassette

Tuberculosis rapid test cassette, also called one-step TB test kit, is a lateral flow chromatographic immunoassay (CIA), TB antibody test cassette and TB IgG/IgM test cassette are available; and TB Dot assay kit is an immuno dot filtration assay kit; both of these POCT test kits are for direct qualitative detection of tuberculosis antibodies in human serum or plasma specimen.

These TB rapid test kits are widely used as an aid in the diagnosis of infection due to Mycobacterium tuberculosis, because they are easy to perform. With serum or plasma samples added to sample well of the rapid TB test cassette, for example, we will get the assay result in about 15 minutes, instead of waiting for days for the testing result with other complicated testing procedure.

About Tuberculosis Disease

Tuberculosis is a highly infectious disease caused by various strains of mycobacteria, usually Mycobacterium tuberculosis (MTB or TB) and potentially fatal disease of human. It is a small bacillus that can withstand weak disinfectants and can survive in a dry state for weeks. It was reported that half of the patients will be killed by the infection, if not treated with antibiotics. And Symptoms include chest pain, coughing up blood, and a productive, prolonged cough for more than three weeks. TB is transmitted almost exclusively by aerosol from the respiratory secretions of patients with active M. tuberculosis. Most of the infected will keep asymptomatic, and about 10% progress to active disease. Tuberculosis mainly affects the lungs and about 80% of all cases of tuberculosis were limited to the lungs. Extra-pulmonary cases most happen to immunosuppressed patients. Morbidity of tuberculosis has been decreasing but recently HIV–associated tuberculosis and multi-drug resistant tuberculosis are on the rise. Persons with silicosis have an approximately 30-fold greater risk for developing TB.

As present, Tuberculosis remains an important socio-economical and medical problem throughout the world. As with other infectious disease, early detection of tuberculosis disease detection will help to reduce and chance of further spread, and will help to the cure of the disease of the infected patients. In this way, these IVD Tuberculosis (TB) Testing devices are contributing to the control of tuberculosis disease. That is why the need for tuberculosis tests will still increase by professional clinical organizations and institutions.

M.Tuberculosis Immunoassay Test Kits

No.Cat. No.Description
(Click For Details)
SpecimenPCS/BoxQuan. per CTN Quantity Interested* Add to
1 TB 811 TB Antibody Serum Test Cassette serum 25 Bulk: 1600 PCS
Boxed: 40 Boxes
2 TB 812 TB IgG/IgM WB Test Cassette serum/WB/plasma 25 Bulk: 1600 PCS
Boxed: 40 Boxes
3 TB 8112 Tuberculosis IgG Dot Assay serum 25 Bulk: 1200 PCS
Boxed: 36 Boxes
4 TB 8124 TB IgG ELISA Kit serum/WB 48/96T Boxed: 40 Kits boxes
5 TB 8134 TB Correlative IFN-γ Release Assay serum/WB 48/96T Boxed: 40 Kits boxes
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  2. TB-IGRA is the application of the latest technology for the diagnosis of M.Tuberculosis.
Tuberculosis (TB) Rapid Test Kit
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