Chikungunya IgG/IgM Rapid Test Cassette
The Chikungunya IgM/IgG Rapid Test is a lateral flow chromatographic immunoassay for the qualitative detection of IgM/IgG to the chikungunya virus in human serum, plasma or whole blood. It is intended to be used as a screening test and as an aid in the diagnosis of infection with Chikungunya disease. Our Chikungunya IgM/IgG Rapid Test utilizes recombinant antigens derived from the structure protein of Chikungunya, and it detects IgM/IgG antibodies to CHIK in human serum, plasma or whole blood within 15 minutes.
Principle
The Chikungunya IgM/IgG Rapid Test consists of: 1) a burgundy colored conjugate pad containing recombinant antigen conjugated with colloid gold (Chikungunya conjugates) and rabbit IgG-gold conjugates, 2) a nitrocellulose membrane strip containing two test bands: the M band is pre-coated with monoclonal anti-human IgM for the detection of IgM anti- Chikungunya, G band is pre-coated with reagents for the detection of IgG anti-Chikungunya, and the C band is pre-coated with goat anti rabbit IgG which acts as an internal control of the assay. When an adequate volume of test specimen is dispensed into the sample well of the test cassette, the specimen migrates by capillary action across the cassette. Anti-CHIK IgM, if present in the specimen, will bind to the CHIK conjugates. The immunocomplex is then captured on the membrane by the pre-coated anti-human IgM antibody, forming a burgundy colored M band, indicating a CHIK IgM positive test result.
Anti-CHIK IgG, if present in the specimen, will bind to the CHIK conjugates. The immunocomplex is then captured by the pre-coated reagents on the membrane, forming a burgundy colored G band, indicating a CHIK IgG positive test result.
Totally absence of the M line and the G line suggests a negative result.
Background Information
Trypanosoma cruzi is a species of parasitic euglenoids. The trypanosomes characteristically bore tissue in human tissue and primarily feed on blood and also lymph. This behaviour causes the disease of trypanosomiasis in humans, usually known as American trypanosomiasis or Chagas Disease, which causes a systemic infection of humans with acute manifestations and long term sequelae. Early infections are treatable with the medication benznidazole or nifurtimox. Medication nearly always results in a cure if given early, but becomes less effective the longer a person has had Chagas disease. When used in chronic disease, medication may only delay or prevent the development of end-stage symptoms. Early diagnosis is helpful to reduce the bad effect of this disease. It is estimated that 16-18 million individuals are infected world-widely, and roughly 50,000 people die each year from chronic Chagas disease (World Health Organization), and it is significantly serious in Latin America.
Chikungunya IgG/IgM Rapid Test cassette
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