Filariaisis IgG/IgM Rapid Test Cassette

Filariaisis IgG/IgM  Rapid Test Cassette

Filariasis IgG/IgM Rapid Test Cassette is a lateral flow immunoassay, for the simultaneous detection and differentiation of IgG and IgM anti-filarial parasites (W. Bancrofti and B. Malayi) in human serum, plasma or whole blood. This filarisis blood test is intended to be used as a blood screening test device, and to be used as an aid in the diagnosis of infection with lymphatic filarial parasites.

Principle

The filariasis test cassette consists of: 1) a burgundy colored conjugate pad containing recombinant W. bancrofti and B. malayi common antigens conjugated with colloid gold (Filariasis conjugates) and rabbit IgG-gold conjugates, 2) a nitrocellulose membrane strip containing two test bands: the M band is pre-coated with monoclonal anti-human IgM for the detection of IgM anti-W. bancrofti and B. malayi, while G band is pre-coated with reagents for the detection of IgG antibodies to the same parasites , and the C band is pre-coated with goat anti rabbit IgG.

When an adequate volume of test specimen is dispensed into the sample well of the cassette, the specimen migrates by capillary action across the cassette. W. bancrofti or B. malayi IgM antibodies, if present in the specimen, will bind to the Filariasis conjugates. The immunocomplex is then captured on the membrane by the pre-coated anti-human IgM antibody, forming a burgundy colored M band, indicating a IgM positive test result.

The W. bancrofti or B. malayi IgG antibodies, if present in the specimen, will bind to the Filariasis conjugates. The immunocomplex is then captured by the pre-coated reagents on the membrane, forming a burgundy colored G band, indicating an IgG positive test result.

Total absence of the M and G test bands and a clear line on the control line suggests a negative result.

Background Information

"The lymphatic filariasis known as Elephantiasis, mainly caused by W. bancrofti and B. malayi, affects about 120 million people over 80 countries. The disease is transmitted to humans by the bites of infected mosquitoes within which the microfilariae sucked from an infected human subject develops into third-stage larvae. Generally, repeated and prolonged exposure to infected larvae is required for establishment of human infection.

Antibody detection provides an early means to detect filarial parasite infection. Presence of IgM to the parasite antigens suggest current infection, whereas IgG corresponds to late stage of infection or historical infection. The Filariasis IgG/IgM Rapid Test uses conserved recombinant antigens to simultaneously detect IgG and IgM to the W. bancrofti and B. malayi parasites with high specificity, while not restricted by the requirement of the nocturnal blood collection in the microfilariae detection method."

Filariasis blood Test Cassette

No.Cat. No.Description
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1 FILA 461 Filariasis IgG/IgM Rapid Test Cassette serum/WB/plasma 25 Bulk: 1600 PCS
Boxed: 40 Boxes
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