Filariasis IgG/IgM Rapid Test
This Filariasis antibody rapid test kit is used as an aid in the diagnosis of infection with lymphatic filarial parasites.
Filariasis IgG/IgM Rapid Test Cassette is a lateral flow immunoassay kit, in which recombinant antigens are used for the simultaneous detection and differentiation of IgG and IgM anti-filarial parasites (W. Bancrofti and B. Malayi) in human serum, plasma or whole blood. This Filariasis blood test is intended to be used as a blood screening test device, and to be used as an aid in the diagnosis of infection with lymphatic filarial parasites.
Reagents Used in the Kit
The filariasis test cassette consists of: 1) a burgundy colored conjugate pad containing recombinant W. bancrofti and B. malayi common antigens conjugated with colloid gold (Filariasis conjugates) and rabbit IgG-gold conjugates, 2) a nitrocellulose membrane strip containing two test bands: the M band is pre-coated with monoclonal anti-human IgM for the detection of IgM anti-W. bancrofti and B. malayi, while G band is pre-coated with reagents for the detection of IgG antibodies to the same parasites , and 3) the C band is pre-coated with goat anti rabbit IgG.
The lymphatic filariasis disease is transmitted to humans by the bites of infected mosquitoes within which the microfilariae sucked from an infected human subject develops into third-stage larvae. Generally, repeated and prolonged exposure to infected larvae is required for establishment of human infection.
Antibody detection provides an early means to detect filarial parasite infection. Presence of IgM to the parasite antigens suggest current infection, whereas IgG corresponds to late stage of infection or historical infection.