Group-A Rotavirus Rapid POCT Test Kits

Group-A Rotavirus Rapid Test Cassette

Atlas Link Technology Co., Ltd is supplying three Rotavirus test kits which suitable to be used as POCT test devices, as shown in the following table, which are all immunoassay intended to be used as an aid in the diagnosis of rotavirus diarrhea. Among them, one-step Rotavirus rapid test cassette is designed to detect group-A rotavirus antigen in human fecal specimens; while Rotavirus IgG Dot Assay and Rotavirus IgM Dot Assay are used to detect IgG and IgM antibodies specific to rotavirus in human plasma or serum.

When gastroenteritis cases happen, diagnosis of rotavirus infection is normally ordered by doctors, because it is as the most common cause of severe diarrhea. Most children admitted to hospital with gastroenteritis are tested for rotavirus-A. Both faeces antigen test and serum antibodies test devices are available. Rotavirus-A Antigen cassette is a rapid testing device to detect group-A specific proteins, including the major inner capsid protein from the Group A rotaviruses, in human stool specimens. This antigen testing cassette of Rotavirus-A is based on the gold colloidal solid phase double antibody sandwich immunochromatography principle, in which two kinds of antibodies specific to rotavirus antigens are used to detect the antigen specifically. While the Rotavirus-A IgG Dot assay and Rotavirus-A IgM Dot assay are testing devices based on the dot immunoassay filtration assay principle, intended to be used to detect the IgG and IgM antibodies specific to rotavirus in human serum. All these kits are used as an aid in the diagnosis of rotavirus infections; and IgG test can also check the immuno status of the human beings.

Principle

Rotavirus Rapid Test Cassette is based on the principle of sandwich immune-chromatography, and utilizes two kinds of antibody in a solid phase sandwich immune-chromatography to detect group-A specific proteins, including the major inner capsid protein, present in Group A rotavirus. When testing with the rotavirus antigen test, if there is rotavirus protein in the specimen added to the sample well of the rotavirus cassette, the protein of the rotavirus will react with the anti-human antibody in the membrane strip first, and will be captured by the recombinant antibody at the test region (T). A red or pink line will appear under the effect of this complex of sandwich structure, indicating a positive result. This one-step rotavirus test is intended to be used as an aid in the diagnosis of rotavirus diarrhea. Early detection of the real causes of the diarrhea symptom will help taking timely measures to treat the disease accordingly.

Background

Rotavirus belongs to the viral family Reoviridae. Scientists have described seven rotavirus groups (A to G), and only groups A, B and C infect humans. Among the three serotypes, rotavirus-A accounts for more than 90% of rotavirus gastroenteritis in humans. Although humans of all ages are susceptible to rotavirus infection, children 6 to 24 months of age account for the vast majority of severe infections.

The symptoms of rotavirus gastroenteritis range from mild to severe, characterized by vomiting, watery diarrhea, and low-grade fever. Dehydration is more common in rotavirus infection than in most of those caused by bacterial pathogens, and is the most common cause of death related to rotavirus infection.

Rotavirus is transmitted by the fecal-oral route, via contact with contaminated hands, surfaces and objects, and possibly by the respiratory route. The faeces of an infected person can contain more than 10 trillion infectious particles per gram; while 10–100 are enough to transmit the infection. And the virus can live very long time in the natural environment, and it seems that the usual sanitary measurement can't kill the virus effectively. Once infected by the rotavirus, the incubation period is about two days before symptoms appear. The infection can reoccur during the life time, and most of the subsequent infections are asymptomatic because of the protection from the antibodies secreted from the first infection. But the asymptomatic patients still can transmit infectious particles. These characters make the rotavirus very epidemic all over the world, both in the developing and developed countries.

Group-A Rotavirus POCT Test Kits

No.Cat. No.Description
(Click For Details)
SpecimenPCS/BoxQuan. per CTN Quantity Interested* Add to
Inquiry
1 RoV 931 Rotavirus AG Test Cassette human faeces 20 Bulk: 1500 PCS
Boxed: 40 Boxes
PCS
2 RoV 9312 Rotavirus IgM Dot Assay serum 25 Bulk: 1200 PCS
Boxed: 36 Boxes
PCS
3 RoV 9322 Rotavirus IgG Dot Assay serum 25 Bulk: 1200 PCS
Boxed: 36 Boxes
PCS
NOTES:
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