Thyroid Stimulating Hormone (TSH) ELISA kit

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The Thyroid Stimulating Hormone (TSH) ELISA kit is immunoassay devices designed for the quantitative determination of thyroid stimulating hormone (TSH) concentration in human serum.

TSH and Dysfunction of Thyroid Gland

The determination of serum or plasma levels of thyroid stimulation hormone (TSH or thyrotropin) is regarded as a sensitive method in the diagnosis dysfunction of thyroid gland. TSH levels are tested in the blood of patients suspected of suffering from excess or deficiency of thyroid hormone. A standard reference range for TSH for adults is between 0.4 and 5.0 mIU/L. The interpretation of the TSH level depends also on the blood levels of thyroid hormones (T3 and T4). If both levels of TSH and thyroid hormone are high, it may caused by benign tumor of the pituitary or thyroid hormone resistance; both are low, hypopituitarism may occur; if TSH high and thyroid hormone low, congenital hypothyroidism or hypothyroidism or Hashimoto's thyroiditis may occur; if TSH low and thyroid hormone high, it may indicate hyperthyroidism or Graves' disease.

The Immunoassay Test kit of TSH

TSH is secreted by the anterior lobe of the pituitary gland and induces the production and release of thyroxine (T4) and triiodothyronine (T3) from the thyroid gland. Although the concentration of TSH in the blood is extremely low, it is essential for the maintenance of normal thyroid function. The release of TSH is regulated by a TSH-releasing hormone (TRH) produced by the hypothalamus. The levels of TSH and TRH are inversely related to the level of thyroid hormone. When there is a high level of thyroid hormone in the blood, less TRH is released by the hypothalamus, so will TSH by the pituitary. In turn, the TSH induced secretion of thyroid hormone will be reduced. The opposite action will occur when the level of thyroid hormone in the blood is low. This process is known as a negative feedback mechanism and responsible for maintaining the proper blood levels of thyroid hormones.

TSH is a glycoprotein with a molecular weight of approximately 28,000 Daltons, consisting of two chemically different subunits, alpha and beta. TSH has identical alpha chains with pituitary glycoproteins, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and human chorionic gonadotropin (HCG). The beta chains are distinct, and determine TSH receptor specificity. The monoclonal antibody in our TSH ELISA test kit is targeted to these beta chains to avoid cross reaction with the above mentioned hormones so as to improve the specificity of the TSH assay kit.

Thyroid Stimulating Hormone (TSH) ELISA Kit

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1 TSH T514 TSH ELISA Kit serum 96T Boxed: 40 Kits boxes
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